The 20th century was the century of physics. What about the 21st? Though progress on some old problems is frustratingly slow, exciting new questions are emerging in condensed matter physics, nonequilibrium thermodynamics and other fields. And most of all, the 21st century is the dawn of the Anthropocene, in which we will adapt to the realities of life on a finite-sized planet. How can physicists help here?You can see a video of my talk, and also my slides: links in blue on my slides lead to more information.